SCOPe 2.05: Domain d4up1b_: 4up1 B:

Lineage for d4up1b_ (4up1 B:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein automated matches [190469] (12 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [189245] (8 PDB entries)

8. Domain d4up1b_: 4up1 B: [274331]
   automated match to d4eb4a_
   complexed with so4

Details for d4up1b_

PDB Entry: 4up1, 2.99 Å

PDB Description: crystal structure of native human thymidylate synthase in active form

PDB Compounds: (B:) Thymidylate synthase

SCOPe Domain Sequences for d4up1b_:

Sequence; same for both SEQRES and ATOM records:

>d4up1b_ d.117.1.1 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pphgelqylgqiqhilrcgvrkddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvl
eellwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgae
yrdmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvn
selscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhiepl
kiqlqreprpfpklrilrkvekiddfkaedfqiegynphptik

Timeline for d4up1b_:

• d4up1b_ is new in SCOPe 2.05-stable
  
• d4up1b_ appears in SCOPe 2.06
  
• d4up1b_ appears in the current release, SCOPe 2.08