Lineage for d4x1la_ (4x1l A:)

  1. Root: SCOPe 2.06
  2. 2170735Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2210472Fold d.110: Profilin-like [55769] (10 superfamilies)
    core: 2 alpha-helices and 5-stranded antiparallel sheet: order 21543; 3 layers: alpha/beta/alpha
  4. 2210473Superfamily d.110.1: Profilin (actin-binding protein) [55770] (2 families) (S)
    alpha-beta(2)-alpha-beta(5)-alpha
  5. 2210474Family d.110.1.1: Profilin (actin-binding protein) [55771] (2 proteins)
    automatically mapped to Pfam PF00235
  6. 2210516Protein automated matches [190412] (8 species)
    not a true protein
  7. 2210525Species Human (Homo sapiens) [TaxId:9606] [187287] (6 PDB entries)
  8. 2210529Domain d4x1la_: 4x1l A: [273758]
    automated match to d2vk3a_
    complexed with po4; mutant

Details for d4x1la_

PDB Entry: 4x1l (more details), 2.16 Å

PDB Description: structural basis for mutation-induced destabilization of profilin 1 in als
PDB Compounds: (A:) Profilin-1

SCOPe Domain Sequences for d4x1la_:

Sequence, based on SEQRES records: (download)

>d4x1la_ d.110.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gwnayidnlmadgtcqdaaivgykdspsvwaavpgktfvnitpaevgvlvgkdrssfyvn
gltlggqkcsvirdsllqdgefsmdlrtkstggaptfnvtvtktdktlvllmgkegvhgg
linkkcyemashlrrsqy

Sequence, based on observed residues (ATOM records): (download)

>d4x1la_ d.110.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gwnayidnlmadgtcqdaaivgykdspsvwaavpgktfvnitpaevgvlvgkdrgltlgg
qkcsvirdsllqdgefsmdlrtkptfnvtvtktdktlvllmgkegvhgglinkkcyemas
hlrrsqy

SCOPe Domain Coordinates for d4x1la_:

Click to download the PDB-style file with coordinates for d4x1la_.
(The format of our PDB-style files is described here.)

Timeline for d4x1la_: