Lineage for d4rvka_ (4rvk A:)

  1. Root: SCOPe 2.07
  2. 2530962Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2586062Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2586063Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2586210Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 2586817Protein Cell cycle checkpoint kinase chk1 [64404] (1 species)
    CaMK group; CAMKL subfamily; serine/threonine kinase
  7. 2586818Species Human (Homo sapiens) [TaxId:9606] [64405] (87 PDB entries)
  8. 2586873Domain d4rvka_: 4rvk A: [273455]
    automated match to d2ydia_
    complexed with 3xk

Details for d4rvka_

PDB Entry: 4rvk (more details), 1.85 Å

PDB Description: chk1 kinase domain with diazacarbazole compound 8: n-[3-(6-cyano-9h- pyrrolo[2,3-b:5,4-c']dipyridin-3-yl)phenyl]acetamide
PDB Compounds: (A:) Serine/threonine-protein kinase Chk1

SCOPe Domain Sequences for d4rvka_:

Sequence, based on SEQRES records: (download)

>d4rvka_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicinkml
nhenvvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylh
gigithrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrr
efhaepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplall
hkilvenpsaritipdikkdrwynkplkkga

Sequence, based on observed residues (ATOM records): (download)

>d4rvka_ d.144.1.7 (A:) Cell cycle checkpoint kinase chk1 {Human (Homo sapiens) [TaxId: 9606]}
vpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmknikkeicinkmlnhenvvk
fyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithr
dikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepv
dvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilven
psaritipdikkdrwynkplkkga

SCOPe Domain Coordinates for d4rvka_:

Click to download the PDB-style file with coordinates for d4rvka_.
(The format of our PDB-style files is described here.)

Timeline for d4rvka_: