SCOPe 2.05: Domain d4tyad_: 4tya D:

Lineage for d4tyad_ (4tya D:)

1. Root: SCOPe 2.05

2. Class e: Multi-domain proteins (alpha and beta) [56572] (68 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (7 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.4: RNA-dependent RNA-polymerase [56694] (3 proteins)

6. Protein automated matches [190260] (26 species)
   not a true protein

7. Species Hepatitis C virus [TaxId:11103] [187048] (40 PDB entries)

8. Domain d4tyad_: 4tya D: [272399]
   automated match to d4mz4a_
   complexed with 3ae

Details for d4tyad_

PDB Entry: 4tya, 2.94 Å

PDB Description: an ligand-observed mass spectrometry-based approach integrated into the fragment based lead discovery pipeline

PDB Compounds: (D:) Polyprotein

SCOPe Domain Sequences for d4tyad_:

Sequence, based on SEQRES records:

>d4tyad_ e.8.1.4 (D:) automated matches {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpip
aasqldlsgwfvagysggdiyh

Sequence, based on observed residues (ATOM records):

>d4tyad_ e.8.1.4 (D:) automated matches {Hepatitis C virus [TaxId: 11103]}
smsytwtgalitpcaaeesklpnsllrhhnmvyattsrsaglrqkkvtfdrlqvlddhyr
dvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhihsvwkd
lledtvtpidttimaknevfcvqrkparlivfpdlgvrvcekmalydvvstlpqvvmgss
ygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdlapear
qaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacraaklqd
ctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydlelitscssnv
svahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthff
sillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrvasclr
klgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkltpisgwfvagysgg
diyh

Timeline for d4tyad_:

• d4tyad_ is new in SCOPe 2.05-stable
  
• d4tyad_ appears in SCOPe 2.06
  
• d4tyad_ appears in the current release, SCOPe 2.08