SCOPe 2.07: Domain d3wsaa_: 3wsa A:

Lineage for d3wsaa_ (3wsa A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.128: Terpenoid synthases [48575] (1 superfamily)
   multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

4. Superfamily a.128.1: Terpenoid synthases [48576] (6 families)
   duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J

5. Family a.128.1.2: Squalene synthase [48580] (2 proteins)
   automatically mapped to Pfam PF00494

6. Protein automated matches [191305] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [190011] (24 PDB entries)

8. Domain d3wsaa_: 3wsa A: [271058]
   automated match to d3vjbc_
   complexed with rwz

Details for d3wsaa_

PDB Entry: 3wsa, 2.9 Å

PDB Description: the tuberculosis drug sq109 inhibits trypanosoma cruzi cell proliferation and acts synergistically with posaconazole

PDB Compounds: (A:) Squalene synthase

SCOPe Domain Sequences for d3wsaa_:

Sequence, based on SEQRES records:

>d3wsaa_ a.128.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvp
llhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigma
efldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktn
iirdyledqqggrefwpqevwsryvkklgdfalpenidlavqclnelitnalhhipdvit
ylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavlirlgqavtlmmdatnmpavk
aiiyqymeeiyhripdsnpsssktrqiistirtq

Sequence, based on observed residues (ATOM records):

>d3wsaa_ a.128.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
lssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvp
llhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigma
efldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktn
iirdyledqqggrefwpqevwsryvkklgdfalpenidlavqclnelitnalhhipdvit
ylsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavlivtlmmdatnmpavkaiiyq
ymeeiyhripdsnpsssktrqiistirtq

Timeline for d3wsaa_:

• d3wsaa_ first appeared in SCOPe 2.05
  
• d3wsaa_ appears in SCOPe 2.06
  
• d3wsaa_ appears in the current release, SCOPe 2.08