SCOPe 2.06: Domain d4oexa1: 4oex A:535-860

Lineage for d4oexa1 (4oex A:535-860)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein automated matches [190370] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187208] (27 PDB entries)

8. Domain d4oexa1: 4oex A:535-860 [270982]
   Other proteins in same PDB: d4oexa2
   automated match to d3ly2a_
   complexed with 5eo, mg, zn

Details for d4oexa1

PDB Entry: 4oex, 2.14 Å

PDB Description: crystal structure of the pde5a1 catalytic domain in complex with novel inhibitors

PDB Compounds: (A:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d4oexa1:

Sequence, based on SEQRES records:

>d4oexa1 a.211.1.2 (A:535-860) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlk
iikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpi
qqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealth
vsedcfplldgcrknrqkwqalaeqq

Sequence, based on observed residues (ATOM records):

>d4oexa1 a.211.1.2 (A:535-860) automated matches {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsyiqrsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailatdl
alyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvate
ffdqgknkipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalaeqq

Timeline for d4oexa1:

• d4oexa1 first appeared in SCOPe 2.05, called d4oexa_
  
• d4oexa1 appears in SCOPe 2.07
  
• d4oexa1 appears in the current release, SCOPe 2.08