SCOPe 2.07: Domain d3wcmd_: 3wcm D:

Lineage for d3wcmd_ (3wcm D:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.128: Terpenoid synthases [48575] (1 superfamily)
   multihelical; core: 8 helices (C-J) are arranged in 2 parallel layers

4. Superfamily a.128.1: Terpenoid synthases [48576] (6 families)
   duplication: two metal-binding sites are related by a pseudo dyad that also relates helices C-F to helices G-J

5. Family a.128.1.2: Squalene synthase [48580] (2 proteins)
   automatically mapped to Pfam PF00494

6. Protein automated matches [191305] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [190011] (24 PDB entries)

8. Domain d3wcmd_: 3wcm D: [265634]
   automated match to d3vjbc_
   complexed with er4

Details for d3wcmd_

PDB Entry: 3wcm, 2.06 Å

PDB Description: The complex structure of HsSQS wtih ligand, ER119884

PDB Compounds: (D:) Squalene synthase

SCOPe Domain Sequences for d3wcmd_:

Sequence, based on SEQRES records:

>d3wcmd_ a.128.1.2 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvpl
lhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigmae
fldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktni
irdyledqqggrefwpqevwsryvkklgdfalpenidlavqclnelitnalhhipdvity
lsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkgavlirlgqavtlmmdatnmpavka
iiyqymeeiyhripdsnpsssktrqiistirtqn

Sequence, based on observed residues (ATOM records):

>d3wcmd_ a.128.1.2 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
ssslktcykylnqtsrsfaaviqaldgemrnavcifylvlraldtleddmtisvekkvpl
lhnfhsflyqpdwrfmeskekdrqvledfptislefrnlaekyqtviadicrrmgigmae
fldkhvtseqewdkychyvaglvgiglsrlfsasefedplvgedteransmglflqktni
irdyledqqggrefwpqevwsryvkklgdfalpenidlavqclnelitnalhhipdvity
lsrlrnqsvfnfcaipqvmaiatlaacynnqqvfkavtlmmdatnmpavkaiiyqymeei
yhripdsnpsssktrqiistirtqn

Timeline for d3wcmd_:

• d3wcmd_ first appeared in SCOPe 2.05
  
• d3wcmd_ appears in SCOPe 2.06
  
• d3wcmd_ appears in the current release, SCOPe 2.08