SCOPe 2.07: Domain d4wcuc_: 4wcu C:

Lineage for d4wcuc_ (4wcu C:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein Catalytic domain of cyclic nucleotide phosphodiesterase pde4d [89151] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89152] (72 PDB entries)
   Uniprot Q08499 388-713

8. Domain d4wcuc_: 4wcu C: [264101]
   automated match to d3g58d_
   complexed with 3kq, mg, zn

Details for d4wcuc_

PDB Entry: 4wcu, 2.35 Å

PDB Description: PDE4 complexed with inhibitor

PDB Compounds: (C:) cAMP-specific 3',5'-cyclic phosphodiesterase 4D

SCOPe Domain Sequences for d4wcuc_:

Sequence, based on SEQRES records:

>d4wcuc_ a.211.1.2 (C:) Catalytic domain of cyclic nucleotide phosphodiesterase pde4d {Human (Homo sapiens) [TaxId: 9606]}
vlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtlitylmtle
dhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdvdhpgvsnq
flintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrkmvidivla
tdmskhmnlladlktmvetkkvtssgvllldnysdriqvlqnmvhcadlsnptkplqlyr
qwtdrimeeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwetwadlvhp
daqdildtlednrewyqstipqspspapddpeegrqgqtekfqfe

Sequence, based on observed residues (ATOM records):

>d4wcuc_ a.211.1.2 (C:) Catalytic domain of cyclic nucleotide phosphodiesterase pde4d {Human (Homo sapiens) [TaxId: 9606]}
vlakeledvnkwglhvfriaelsgnrpltvimhtifqerdllktfkipvdtlitylmtle
dhyhadvayhnnihaadvvqsthvllstpaleavftdleilaaifasaihdvdhpgvsnq
flintnselalmyndssvlenhhlavgfkllqeencdifqnltkkqrqslrkmvidivla
tdmskhmnlladlktmvetkkllldnysdriqvlqnmvhcadlsnptkplqlyrqwtdri
meeffrqgdrerergmeispmcdkhnasveksqvgfidyivhplwetwadlvhpdaqdil
dtlednrewyqstiptekfqfe

Timeline for d4wcuc_:

• d4wcuc_ first appeared in SCOPe 2.05
  
• d4wcuc_ appears in SCOPe 2.06
  
• d4wcuc_ appears in the current release, SCOPe 2.08