SCOPe 2.07: Domain d4riyc_: 4riy C:

Lineage for d4riyc_ (4riy C:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (35 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1319 PDB entries)

8. Domain d4riyc_: 4riy C: [261972]
   Other proteins in same PDB: d4riyb_, d4riyd_
   automated match to d3kexa_
   complexed with adp, anp, mg; mutant

Details for d4riyc_

PDB Entry: 4riy, 2.98 Å

PDB Description: Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation

PDB Compounds: (C:) Receptor tyrosine-protein kinase erbB-3

SCOPe Domain Sequences for d4riyc_:

Sequence, based on SEQRES records:

>d4riyc_ d.144.1.0 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviedksgrqsfqavtd
hmlaigsldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgpqlllnwgvqi
akgmyyleehgmvhrnlaarnvllkspsqvqvadfgvadllppddkqllyseaktpikwm
alesihfgkythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekggrlaqpqicti
dvymvmvkcwmidenirptfkelaneftrmardpprylvik

Sequence, based on observed residues (ATOM records):

>d4riyc_ d.144.1.0 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviesfqavtdhmlaig
sldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgpqlllnwgvqiakgmyy
leehgmvhrnlaarnvllkspsqvqvadfgvadllppddkqllyseaktpikwmalesih
fgkythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekggrlaqpqictidvymvm
vkcwmidenirptfkelaneftrmardpprylvik

Timeline for d4riyc_:

• d4riyc_ first appeared in SCOPe 2.04
  
• d4riyc_ appears in SCOPe 2.06
  
• d4riyc_ appears in the current release, SCOPe 2.08