SCOPe 2.05: Domain d4nd1b2: 4nd1 B:165-333

Lineage for d4nd1b2 (4nd1 B:165-333)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.162: LDH C-terminal domain-like [56326] (1 superfamily)
   unusual fold, defines family

4. Superfamily d.162.1: LDH C-terminal domain-like [56327] (3 families)

5. Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain [56328] (5 proteins)
   N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)
   automatically mapped to Pfam PF02866

6. Protein Lactate dehydrogenase [56339] (18 species)

7. Species Cryptosporidium parvum [TaxId:5807] [225186] (6 PDB entries)

8. Domain d4nd1b2: 4nd1 B:165-333 [261823]
   Other proteins in same PDB: d4nd1a1, d4nd1b1
   automated match to d2ewda2
   complexed with gol, nad, oxm

Details for d4nd1b2

PDB Entry: 4nd1, 2.15 Å

PDB Description: crystal structure of the lactate dehydrogenase from cryptosporidium parvum complexed with cofactor (b-nicotinamide adenine dinucleotide) and inhibitor (oxamic acid)

PDB Compounds: (B:) Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase

SCOPe Domain Sequences for d4nd1b2:

Sequence; same for both SEQRES and ATOM records:

>d4nd1b2 d.162.1.1 (B:165-333) Lactate dehydrogenase {Cryptosporidium parvum [TaxId: 5807]}
gvldssrfrtfiaqhfgvnasdvsanvigghgdgmvpatssvsvggvplssfikqglitq
eqideivchtriawkevadnlktgtayfapaaaavkmaeaylkdkkavvpcsafcsnhyg
vkgiymgvptiigkngvedileldltpleqkllgesinevntiskvldnap

Timeline for d4nd1b2:

• d4nd1b2 first appeared in SCOPe 2.04
  
• d4nd1b2 appears in SCOPe 2.06
  
• d4nd1b2 appears in the current release, SCOPe 2.08