SCOPe 2.05: Domain d4mpca2: 4mpc A:182-394

Lineage for d4mpca2 (4mpc A:182-394)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.4: alpha-ketoacid dehydrogenase kinase, C-terminal domain [69804] (3 proteins)

6. Protein automated matches [230554] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [230555] (13 PDB entries)

8. Domain d4mpca2: 4mpc A:182-394 [253822]
   Other proteins in same PDB: d4mpca1
   automated match to d2bu8a2
   complexed with pv2, tla

Details for d4mpca2

PDB Entry: 4mpc, 1.7 Å

PDB Description: Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS2

PDB Compounds: (A:) [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial

SCOPe Domain Sequences for d4mpca2:

Sequence, based on SEQRES records:

>d4mpca2 d.122.1.4 (A:182-394) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pahpkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyv
pshlyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkie
rlfsymystaptpqpgtggtplagfgyglpisrlyakyfqgdlqlfsmegfgtdaviylk
alstdsverlpvynksawrhyqtiqeagdwcvp

Sequence, based on observed residues (ATOM records):

>d4mpca2 d.122.1.4 (A:182-394) automated matches {Human (Homo sapiens) [TaxId: 9606]}
pahpkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyv
pshlyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkie
rlfsymystgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynks
awrhyqtiqeagdwcvp

Timeline for d4mpca2:

• d4mpca2 first appeared in SCOPe 2.04
  
• d4mpca2 appears in SCOPe 2.06
  
• d4mpca2 appears in the current release, SCOPe 2.08