SCOPe 2.04: Domain d4hfyb_: 4hfy B:

Lineage for d4hfyb_ (4hfy B:)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (48 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (169 PDB entries)
   Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

8. Domain d4hfyb_: 4hfy B: [252441]
   automated match to d3sqhe_
   mutant

Details for d4hfyb_

PDB Entry: 4hfy, 3 Å

PDB Description: Structure of prethrombin-2 mutant S195A bound to the active site inhibitor argatroban

PDB Compounds: (B:) Prothrombin

SCOPe Domain Sequences for d4hfyb_:

Sequence, based on SEQRES records:

>d4hfyb_ b.47.1.2 (B:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
eadcglrplfekksledkterellesyidgrivegsdaeigmspwqvmlfrkspqellcg
aslisdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihpr
ynwrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwt
anvgkgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdaggpf
vmkspfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidqfge

Sequence, based on observed residues (ATOM records):

>d4hfyb_ b.47.1.2 (B:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
eadcglrplfekksledkterellesyidgrivegsdaeigmspwqvmlfrkspqellcg
aslisdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihpr
ynwrenldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwt
apsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdaggpfvmkspf
nnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidqfge

Timeline for d4hfyb_:

• d4hfyb_ is new in SCOPe 2.04-stable
  
• d4hfyb_ does not appear in SCOPe 2.05