SCOPe 2.05: Domain d4dfye_: 4dfy E:

Lineage for d4dfye_ (4dfy E:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein cAMP-dependent PK, catalytic subunit [56116] (5 species)
   AGC group; PKA subfamily; serine/threonine kinase

7. Species Mouse (Mus musculus) [TaxId:10090] [56119] (29 PDB entries)

8. Domain d4dfye_: 4dfy E: [251438]
   automated match to d3qame_
   mutant

Details for d4dfye_

PDB Entry: 4dfy, 3 Å

PDB Description: Crystal structure of R194A mutant of cAMP-dependent protein kinase with unphosphorylated activation loop

PDB Compounds: (E:) cAMP-dependent protein kinase catalytic subunit alpha

SCOPe Domain Sequences for d4dfye_:

Sequence, based on SEQRES records:

>d4dfye_ d.144.1.7 (E:) cAMP-dependent PK, catalytic subunit {Mouse (Mus musculus) [TaxId: 10090]}
svkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlvkhkesgnhyamki
ldkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvaggemfshlr
rigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfakrvkg
atwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivsg
kvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkveap
fipkfkgpgdtsnfddyeeeeirvsinekcgkeftef

Sequence, based on observed residues (ATOM records):

>d4dfye_ d.144.1.7 (E:) cAMP-dependent PK, catalytic subunit {Mouse (Mus musculus) [TaxId: 10090]}
svkeflakakedflkkwetpsqntaqldqfdriktlgtgsfgrvmlvkhkesgnhyamki
ldkqkvvklkqiehtlnekrilqavnfpflvklefsfkdnsnlymvmeyvaggemfshlr
rigrfsepharfyaaqivltfeylhsldliyrdlkpenllidqqgyiqvtdfgfacgtpe
ylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivsgkvrfpshfss
dlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkveapfipkfeeirv
sinekcgkeftef

Timeline for d4dfye_:

• d4dfye_ first appeared in SCOPe 2.04
  
• d4dfye_ appears in SCOPe 2.06
  
• d4dfye_ appears in the current release, SCOPe 2.08