SCOPe 2.06: Domain d4by0b1: 4by0 B:32-476

Lineage for d4by0b1 (4by0 B:32-476)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.104: Cytochrome P450 [48263] (1 superfamily)
   multihelical

4. Superfamily a.104.1: Cytochrome P450 [48264] (2 families)

5. Family a.104.1.0: automated matches [191509] (1 protein)
   not a true family

6. Protein automated matches [190847] (64 species)
   not a true protein

7. Species Trypanosoma cruzi [TaxId:5693] [196511] (10 PDB entries)

8. Domain d4by0b1: 4by0 B:32-476 [251328]
   Other proteins in same PDB: d4by0a2, d4by0b2
   automated match to d3khma_
   complexed with 5ps, hem

Details for d4by0b1

PDB Entry: 4by0, 3.1 Å

PDB Description: Crystal structure of Trypanosoma cruzi CYP51 bound to the inhibitor (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-3,3'- difluoro-(1,1'-biphenyl)-4-carboxamide

PDB Compounds: (B:) Sterol 14-alpha demethylase

SCOPe Domain Sequences for d4by0b1:

Sequence, based on SEQRES records:

>d4by0b1 a.104.1.0 (B:32-476) automated matches {Trypanosoma cruzi [TaxId: 5693]}
ppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehsrffs
prneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhevr
kfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskmesslipa
avfmpwllrlplpqsarcrearaelqkilgeiivarekeeaskdnntsdllggllkavyr
dgtrmslhevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaqln
ydnvmdempfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhde
eafpnprlwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrde
vpdpdyhtmvvgptlnqclvkytrk

Sequence, based on observed residues (ATOM records):

>d4by0b1 a.104.1.0 (B:32-476) automated matches {Trypanosoma cruzi [TaxId: 5693]}
ppvypvtvpflghivqfgknplefmqrckrdlksgvftisiggqrvtivgdphehsrffs
prneilsprevytimtpvfgegvayaapyprmreqlnflaeeltiakfqnfvpaiqhevr
kfmaenwkedegvinlledcgamiintacqclfgedlrkrlnarhfaqllskmesslipa
avfmpwllrlplpqsarcrearaelqkilgeiivarekeeatsdllggllkavyrdgtrm
slhevcgmivaamfagqhtstittswsmlhlmhpknkkwldklhkeidefpaqlnydnvm
dempfaercvresirrdppllmvmrmvkaevkvgsyvvpkgdiiacspllshhdeeafpn
prlwdperdekvdgafigfgagvhkcigqkfallqvktilatafreydfqllrdevpdpd
yhtmvvgptlnqclvkytrk

Timeline for d4by0b1:

• d4by0b1 first appeared in SCOPe 2.04, called d4by0b_
  
• d4by0b1 was called d4by0b_ in SCOPe 2.05
  
• d4by0b1 appears in SCOPe 2.07
  
• d4by0b1 appears in the current release, SCOPe 2.08