SCOPe 2.04: Domain d4bdga_: 4bdg A:

Lineage for d4bdga_ (4bdg A:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (19 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (476 PDB entries)

8. Domain d4bdga_: 4bdg A: [251219]
   automated match to d2ycfa_
   complexed with cl, edo, no3, p3j

Details for d4bdga_

PDB Entry: 4bdg, 2.84 Å

PDB Description: Fragment-based screening identifies a new area for inhibitor binding to checkpoint kinase 2 (CHK2)

PDB Compounds: (A:) serine/threonine-protein kinase chk2

SCOPe Domain Sequences for d4bdga_:

Sequence, based on SEQRES records:

>d4bdga_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
msvypkalrdeyimsktlgsgacgevklaferktckkvaikiiskrkfaigsareadpal
nveteieilkklnhpciikiknffdaedyyivlelmeggelfdkvvgnkrlkeatcklyf
yqmllavqylhengiihrdlkpenvllssqeedclikitdfghskilgetslmrtlcgtp
tylapevlvsvgtagynravdcwslgvilficlsgyppfsehrtqvslkdqitsgkynfi
pevwaevsekaldlvkkllvvdpkarftteealrhpwlqdedmkrkfqdllseenestal
pqvl

Sequence, based on observed residues (ATOM records):

>d4bdga_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
msvypkalrdeyimsktlgsgevklaferktckkvaikiisknveteieilkklnhpcii
kiknffdaedyyivlelmeggelfdkvvgnkrlkeatcklyfyqmllavqylhengiihr
dlkpenvllssqeedclikitdfghskilgetslmrtlcgtptylapevlvsvgtagynr
avdcwslgvilficlsgyppfsehrtqvslkdqitsgkynfipevwaevsekaldlvkkl
lvvdpkarftteealrhpwlqdedmkrkfqdllseenestalpqvl

Timeline for d4bdga_:

• d4bdga_ is new in SCOPe 2.04-stable
  
• d4bdga_ appears in SCOPe 2.05
  
• d4bdga_ appears in the current release, SCOPe 2.08, called d4bdga1