SCOPe 2.08: Domain d3zw3a3: 3zw3 A:726-1090

Lineage for d3zw3a3 (3zw3 A:726-1090)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d3zw3a3: 3zw3 A:726-1090 [250881]
   Other proteins in same PDB: d3zw3a1, d3zw3a2
   automated match to d1e7ua4
   complexed with zw3

Details for d3zw3a3

PDB Entry: 3zw3, 2.8 Å

PDB Description: fragment based discovery of a novel and selective pi3 kinase inhibitor

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3zw3a3:

Sequence, based on SEQRES records:

>d3zw3a3 d.144.1.0 (A:726-1090) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wflhl

Sequence, based on observed residues (ATOM records):

>d3zw3a3 d.144.1.0 (A:726-1090) automated matches {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsssqvisqlkqklenlqnsqlpesfrvpydpgl
kagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrim
esiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwl
kekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgn
yrvpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmp
qltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhl

Timeline for d3zw3a3:

• d3zw3a3 first appeared in SCOPe 2.04
  
• d3zw3a3 appears in SCOPe 2.07