Lineage for d3tl5a1 (3tl5 A:144-321)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2158219Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
    core: beta(2)-alpha-beta(2); mixed beta-sheet 2143
  4. 2158220Superfamily d.15.1: Ubiquitin-like [54236] (11 families) (S)
  5. 2159292Family d.15.1.5: Ras-binding domain, RBD [54263] (14 protein domains)
    contains Pfam PF00788 and Pfam PF02196
  6. 2159312Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
    includes parts of the flanking linkers
  7. 2159313Species Human (Homo sapiens) [TaxId:9606] [54276] (59 PDB entries)
  8. 2159328Domain d3tl5a1: 3tl5 A:144-321 [249949]
    Other proteins in same PDB: d3tl5a2, d3tl5a3, d3tl5a4, d3tl5a5
    automated match to d1e7ua3
    complexed with 980

Details for d3tl5a1

PDB Entry: 3tl5 (more details), 2.79 Å

PDB Description: Discovery of GDC-0980: a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor for the Treatment of Cancer
PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3tl5a1:

Sequence, based on SEQRES records: (download)

>d3tl5a1 d.15.1.5 (A:144-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}

Sequence, based on observed residues (ATOM records): (download)

>d3tl5a1 d.15.1.5 (A:144-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d3tl5a1:

Click to download the PDB-style file with coordinates for d3tl5a1.
(The format of our PDB-style files is described here.)

Timeline for d3tl5a1: