SCOPe 2.06: Domain d3ps6a3: 3ps6 A:526-725

Lineage for d3ps6a3 (3ps6 A:526-725)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (25 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.1: ARM repeat [48371] (26 families)

5. Family a.118.1.6: Phoshoinositide 3-kinase (PI3K) helical domain [48399] (1 protein)
   automatically mapped to Pfam PF00613
   this is a repeat family; one repeat unit is 1e8y A:598-635 found in domain

6. Protein Phoshoinositide 3-kinase (PI3K) helical domain [48400] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48402] (65 PDB entries)

8. Domain d3ps6a3: 3ps6 A:526-725 [248642]
   Other proteins in same PDB: d3ps6a1, d3ps6a2, d3ps6a4
   automated match to d1e7ua1
   complexed with 3ps

Details for d3ps6a3

PDB Entry: 3ps6, 2.6 Å

PDB Description: quinazolines with intra-molecular hydrogen bonding scaffold (imhbs) as pi3k/mtor dual inhibitors.

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3ps6a3:

Sequence, based on SEQRES records:

>d3ps6a3 a.118.1.6 (A:526-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens) [TaxId: 9606]}
pialpkhqptpdpegdrvraempnqlrkqleaiiatdplnpltaedkellwhfryeslkh
pkaypklfssvkwgqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiav
qklesledddvlhyllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaq
srhyqqrfavileaylrgcg

Sequence, based on observed residues (ATOM records):

>d3ps6a3 a.118.1.6 (A:526-725) Phoshoinositide 3-kinase (PI3K) helical domain {Human (Homo sapiens) [TaxId: 9606]}
pialpraempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssvkw
gqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddvlh
yllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavile
aylrgcg

Timeline for d3ps6a3:

• d3ps6a3 first appeared in SCOPe 2.04
  
• d3ps6a3 appears in SCOPe 2.05
  
• d3ps6a3 appears in SCOPe 2.07
  
• d3ps6a3 appears in the current release, SCOPe 2.08