SCOPe 2.08: Domain d3nzsa1: 3nzs A:147-320

Lineage for d3nzsa1 (3nzs A:147-320)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (15 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (11 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
   contains Pfam PF00788 and Pfam PF02196

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Human (Homo sapiens) [TaxId:9606] [54276] (77 PDB entries)

8. Domain d3nzsa1: 3nzs A:147-320 [248103]
   Other proteins in same PDB: d3nzsa2, d3nzsa3, d3nzsa4
   automated match to d1e7ua3
   complexed with nzs
   has additional insertions and/or extensions that are not grouped together

Details for d3nzsa1

PDB Entry: 3nzs, 2.75 Å

PDB Description: Structure-based Optimization of Pyrazolo -Pyrimidine and -Pyridine Inhibitors of PI3-Kinase

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3nzsa1:

Sequence, based on SEQRES records:

>d3nzsa1 d.15.1.5 (A:147-320) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
sqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvtskp
lpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipesqs
eqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrk

Sequence, based on observed residues (ATOM records):

>d3nzsa1 d.15.1.5 (A:147-320) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
sqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvtskp
lpeylwkkianncifivihrsttsqtikvspddtpgailqsfftdfvlrvcgrdeylvge
tpiknfqwvrhclkngeeihvvldtppdpaldevrk

Timeline for d3nzsa1:

• d3nzsa1 first appeared in SCOPe 2.04
  
• d3nzsa1 appears in SCOPe 2.07