SCOPe 2.07: Domain d3lvpa_: 3lvp A:

Lineage for d3lvpa_ (3lvp A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Insulin-like growth factor 1 receptor [69825] (1 species)
   PTK group; InsR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [69826] (18 PDB entries)

8. Domain d3lvpa_: 3lvp A: [247523]
   automated match to d1p4ob_
   complexed with epe, pdr, so4

Details for d3lvpa_

PDB Entry: 3lvp, 3 Å

PDB Description: Crystal structure of bisphosphorylated IGF1-R Kinase domain (2P) in complex with a bis-azaindole inhibitor

PDB Compounds: (A:) insulin-like growth factor 1 receptor

SCOPe Domain Sequences for d3lvpa_:

Sequence, based on SEQRES records:

>d3lvpa_ d.144.1.7 (A:) Insulin-like growth factor 1 receptor {Human (Homo sapiens) [TaxId: 9606]}
pdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmreriefl
neasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpemennpvlapps
lskmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyetdyyrk
ggkgllpvrwmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmeg
glldkpdncpdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseenk

Sequence, based on observed residues (ATOM records):

>d3lvpa_ d.144.1.7 (A:) Insulin-like growth factor 1 receptor {Human (Homo sapiens) [TaxId: 9606]}
pdewevarekitmsrelgqgsfgmvyegvakgvvkdepetrvaiktvneaasmreriefl
neasvmkefnchhvvrllgvvsqgqptlvimelmtrgdlksylrslrpemepvlappsls
kmiqmageiadgmaylnankfvhrdlaarncmvaedftvkigdfgmtrdiyggkgllpvr
wmspeslkdgvfttysdvwsfgvvlweiatlaeqpyqglsneqvlrfvmegglldkpdnc
pdmlfelmrmcwqynpkmrpsfleiissikeemepgfrevsfyyseenk

Timeline for d3lvpa_:

• d3lvpa_ first appeared in SCOPe 2.04
  
• d3lvpa_ appears in SCOPe 2.06
  
• d3lvpa_ appears in the current release, SCOPe 2.08