SCOPe 2.04: Domain d3l08a1: 3l08 A:144-321

Lineage for d3l08a1 (3l08 A:144-321)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.15: beta-Grasp (ubiquitin-like) [54235] (14 superfamilies)
   core: beta(2)-alpha-beta(2); mixed beta-sheet 2143

4. Superfamily d.15.1: Ubiquitin-like [54236] (9 families)

5. Family d.15.1.5: Ras-binding domain, RBD [54263] (14 proteins)
   contains Pfam PF00788 and Pfam PF02196

6. Protein Phoshoinositide 3-kinase (PI3K) [54274] (2 species)
   includes parts of the flanking linkers

7. Species Human (Homo sapiens) [TaxId:9606] [54276] (57 PDB entries)

8. Domain d3l08a1: 3l08 A:144-321 [247307]
   Other proteins in same PDB: d3l08a2, d3l08a3, d3l08a4
   automated match to d1e7ua3
   complexed with so4, zig

Details for d3l08a1

PDB Entry: 3l08, 2.7 Å

PDB Description: structure of pi3k gamma with a potent inhibitor: gsk2126458

PDB Compounds: (A:) phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

SCOPe Domain Sequences for d3l08a1:

Sequence, based on SEQRES records:

>d3l08a1 d.15.1.5 (A:144-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipe
sqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrke

Sequence, based on observed residues (ATOM records):

>d3l08a1 d.15.1.5 (A:144-321) Phoshoinositide 3-kinase (PI3K) {Human (Homo sapiens) [TaxId: 9606]}
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkdfvlrvcgrdey
lvgetpiknfqwvrhclkngeeihvvldtppdpaldevrke

Timeline for d3l08a1:

• d3l08a1 is new in SCOPe 2.04-stable
  
• d3l08a1 appears in SCOPe 2.05
  
• d3l08a1 appears in the current release, SCOPe 2.08