SCOPe 2.06: Domain d2w2pa_: 2w2p A:

Lineage for d2w2pa_ (2w2p A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.41: Subtilisin-like [52742] (1 superfamily)
   3 layers: a/b/a, parallel beta-sheet of 7 strands, order 2314567; left-handed crossover connection between strands 2 & 3

4. Superfamily c.41.1: Subtilisin-like [52743] (3 families)

5. Family c.41.1.0: automated matches [191390] (1 protein)
   not a true family

6. Protein automated matches [190500] (8 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [255634] (7 PDB entries)

8. Domain d2w2pa_: 2w2p A: [244019]
   Other proteins in same PDB: d2w2pe1, d2w2pe2
   automated match to d1s2nb_
   complexed with ca; mutant

Details for d2w2pa_

PDB Entry: 2w2p, 2.62 Å

PDB Description: pcsk9-deltac d374a mutant bound to wt egf-a of ldlr

PDB Compounds: (A:) Proprotein convertase subtilisin/kexin type 9

SCOPe Domain Sequences for d2w2pa_:

Sequence, based on SEQRES records:

>d2w2pa_ c.41.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sipwnleritppryradeyqppdggslvevylldtsiqsdhreiegrvmvtdfenvpeed
gtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefir
ksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasape
vitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassacstcfvsqsgtsqaaahv
agiaammlsaepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalpps

Sequence, based on observed residues (ATOM records):

>d2w2pa_ c.41.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
sipwnleritpprlvevylldtsiqsdhreiegrvmvtdfenvpeedskcdshgthlagv
vsgrdagvakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvgplvvllplaggy
srvlnaacqrlaragvvlvtaagnfrddaclyspasapevitvgatnaqdqpvtlgtlgt
nfgrcvdlfapgediigassacstcfvsqsgtsqaaahvagiaammlsaepeltlaelrq
rlihfsakdvineawfpedqrvltpnlvaalpps

Timeline for d2w2pa_:

• d2w2pa_ first appeared in SCOPe 2.04
  
• d2w2pa_ appears in SCOPe 2.05
  
• d2w2pa_ appears in SCOPe 2.07
  
• d2w2pa_ appears in the current release, SCOPe 2.08