SCOPe 2.06: Domain d2no0b_: 2no0 B:

Lineage for d2no0b_ (2no0 B:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.37: P-loop containing nucleoside triphosphate hydrolases [52539] (1 superfamily)
   3 layers: a/b/a, parallel or mixed beta-sheets of variable sizes

4. Superfamily c.37.1: P-loop containing nucleoside triphosphate hydrolases [52540] (26 families)
   division into families based on beta-sheet topologies

5. Family c.37.1.1: Nucleotide and nucleoside kinases [52541] (21 proteins)
   parallel beta-sheet of 5 strands, order 23145

6. Protein Deoxycytidine kinase [89657] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [89658] (45 PDB entries)

8. Domain d2no0b_: 2no0 B: [243202]
   automated match to d1p60a_
   complexed with adp, geo

Details for d2no0b_

PDB Entry: 2no0, 1.8 Å

PDB Description: c4s dck variant of dck in complex with gemcitabine+adp

PDB Compounds: (B:) Deoxycytidine kinase

SCOPe Domain Sequences for d2no0b_:

Sequence, based on SEQRES records:

>d2no0b_ c.37.1.1 (B:) Deoxycytidine kinase {Human (Homo sapiens) [TaxId: 9606]}
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvqstqdefeeltmsqkngg
nvlqmmyekperwsftfqtyaclsriraqlaslngklkdaekpvlffersvysdryifas
nlyesesmnetewtiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqg
ipleyleklhykheswllhrtlktnfdylqevpiltldvnedfkdkyeslvekvkeflst
l

Sequence, based on observed residues (ATOM records):

>d2no0b_ c.37.1.1 (B:) Deoxycytidine kinase {Human (Homo sapiens) [TaxId: 9606]}
rikkisiegniaagkstfvnilkqlsedwevvpepvarwsnvqstnggnvlqmmyekper
wsftfqtyaclsriraqlaslngkldaekpvlffersvysdryifasnlyesesmnetew
tiyqdwhdwmnnqfgqsleldgiiylqatpetclhriylrgrneeqgipleyleklhykh
eswllhrtlktnfdylqevpiltldvnedfyeslvekvkeflstl

Timeline for d2no0b_:

• d2no0b_ first appeared in SCOPe 2.04
  
• d2no0b_ appears in SCOPe 2.05
  
• d2no0b_ appears in SCOPe 2.07
  
• d2no0b_ appears in the current release, SCOPe 2.08