SCOPe 2.08: Domain d4mmfb_: 4mmf B:

Lineage for d4mmfb_ (4mmf B:)

1. Root: SCOPe 2.08

2. Class f: Membrane and cell surface proteins and peptides [56835] (69 folds)

3. Fold f.54: SNF-like [161069] (1 superfamily)
   12 transmembrane helices; duplication: consists of two structurally similar halves

4. Superfamily f.54.1: SNF-like [161070] (3 families)

5. Family f.54.1.1: SNF-like [161071] (2 proteins)
   Pfam PF00209; Sodium:neurotransmitter symporter

6. Protein Na(+):neurotransmitter symporter homologue LeuT [161072] (1 species)

7. Species Aquifex aeolicus [TaxId:63363] [161073] (43 PDB entries)
   Uniprot O67854 5-513

8. Domain d4mmfb_: 4mmf B: [235676]
   automated match to d4mmfa_
   complexed with 29q, bog, na; mutant

Details for d4mmfb_

PDB Entry: 4mmf, 2.7 Å

PDB Description: crystal structure of leubat (delta5 mutant) in complex with mazindol

PDB Compounds: (B:) Transporter

SCOPe Domain Sequences for d4mmfb_:

Sequence, based on SEQRES records:

>d4mmfb_ f.54.1.1 (B:) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
rehwatrlglilamagyavdlgnflrfpvqaaengggafmipyiiafllvgiplmwiewa
mgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikflv
glvpepppnatdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsili
rgiskgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvw
iaavgqiffslglgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaava
ffgvanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiagmqpmi
afledelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiff
wifgadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtvw
itrfyiiglflfltflvflaerrrnhe

Sequence, based on observed residues (ATOM records):

>d4mmfb_ f.54.1.1 (B:) Na(+):neurotransmitter symporter homologue LeuT {Aquifex aeolicus [TaxId: 63363]}
rehwatrlglilamagyavdlgnflrfpvqaaengggafmipyiiafllvgiplmwiewa
mgryggaqghgttpaifyllwrnrfakilgvfglwiplvvaiyyvyieswtlgfaikflv
glvpepptdpdsilrpfkeflysyigvpkgdepilkpslfayivflitmfinvsilirgi
skgierfakiamptlfilavflvirvflletpngtaadglnflwtpdfeklkdpgvwiaa
vgqiffslglgfgaiityasyvrkdqdivlsgltaatlnekaevilggsisipaavaffg
vanavaiakagafnlgfitlpaifsqtaggtflgflwffllffagltssiagmqpmiafl
edelklsrkhavlwtaaivffsahlvmflnksldemdfwagtigvvffglteliiffwif
gadkaweeinrggiikvpriyyyvmryitpaflavllvvwareyipkimeethwtvwitr
fyiiglflfltflvflaerrrnhe

Timeline for d4mmfb_:

• d4mmfb_ first appeared in SCOPe 2.03
  
• d4mmfb_ appears in SCOPe 2.07