SCOPe 2.06: Domain d4is8b_: 4is8 B:

Lineage for d4is8b_ (4is8 B:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein automated matches [190059] (14 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187214] (173 PDB entries)

8. Domain d4is8b_: 4is8 B: [234902]
   automated match to d4is8a_

Details for d4is8b_

PDB Entry: 4is8, 2.78 Å

PDB Description: Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors

PDB Compounds: (B:) Nuclear receptor subfamily 5 group A member 2

SCOPe Domain Sequences for d4is8b_:

Sequence, based on SEQRES records:

>d4is8b_ a.123.1.1 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
siphlilellkcepdepqvqakimaylqqeqanrskheklstfglmckmadqtlfsivew
arssiffrelkvddqmkllqncwsellildhiyrqvvhgkegsiflvtgqqvdysiiash
tevafnnlmshaqelvaklrslqfdqrefvclkflvlfsldvknlenfqlvegvqeqvna
alldytmcnypqqtekfgqlllrlpeiraismqaeeylyykhlngdvpynnlliemlha

Sequence, based on observed residues (ATOM records):

>d4is8b_ a.123.1.1 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
siphlilellkcepdepqvqakimaylqqeqaklstfglmckmadqtlfsivewarssif
frelkvddqmkllqncwsellildhiyrqvvhgkegsiflvtgqqvdysiiashtevafn
nlmshaqelvaklrslqfdqrefvclkflvlfsldvknlenfqlvegvqeqvnaalldyt
mcnypqqtekfgqlllrlpeiraismqaeeylyykhlngdvplliemlha

Timeline for d4is8b_:

• d4is8b_ first appeared in SCOPe 2.03
  
• d4is8b_ appears in SCOPe 2.05
  
• d4is8b_ appears in SCOPe 2.07
  
• d4is8b_ appears in the current release, SCOPe 2.08