SCOPe 2.08: Domain d4cfnd1: 4cfn D:176-309

Lineage for d4cfnd1 (4cfn D:176-309)

1. Root: SCOPe 2.08

2. Class a: All alpha proteins [46456] (290 folds)

3. Fold a.74: Cyclin-like [47953] (1 superfamily)
   core: 5 helices; one helix is surrounded by the others

4. Superfamily a.74.1: Cyclin-like [47954] (4 families)
   duplication: consists of two domains of this fold

5. Family a.74.1.1: Cyclin [47955] (9 proteins)

6. Protein Cyclin A [47956] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47957] (89 PDB entries)
   Uniprot P20248 175-432

8. Domain d4cfnd1: 4cfn D:176-309 [229786]
   Other proteins in same PDB: d4cfna1, d4cfna2, d4cfnc1, d4cfnc2
   automated match to d1h1pb1
   complexed with dtt, jym

Details for d4cfnd1

PDB Entry: 4cfn, 2.2 Å

PDB Description: Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.

PDB Compounds: (D:) Cyclin-A2

SCOPe Domain Sequences for d4cfnd1:

Sequence, based on SEQRES records:

>d4cfnd1 a.74.1.1 (D:176-309) Cyclin A {Human (Homo sapiens) [TaxId: 9606]}
pdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhla
vnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrme
hlvlkvltfdlaap

Sequence, based on observed residues (ATOM records):

>d4cfnd1 a.74.1.1 (D:176-309) Cyclin A {Human (Homo sapiens) [TaxId: 9606]}
pdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhla
vnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyittytkkqvlrmehl
vlkvltfdlaap

Timeline for d4cfnd1:

• d4cfnd1 first appeared in SCOPe 2.03
  
• d4cfnd1 appears in SCOPe 2.07