Lineage for d4jpea1 (4jpe A:45-440)

  1. Root: SCOPe 2.07
  2. 2344607Class b: All beta proteins [48724] (178 folds)
  3. 2391025Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2391026Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2392462Family b.50.1.2: Pepsin-like [50646] (11 protein domains)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10
  6. 2392520Protein beta-secretase (memapsin) [50671] (1 species)
  7. 2392521Species Human (Homo sapiens) [TaxId:9606] [50672] (283 PDB entries)
    Uniprot P56817 58-446 ! Uniprot P56817 60-447
  8. 2392669Domain d4jpea1: 4jpe A:45-440 [223929]
    Other proteins in same PDB: d4jpea2
    automated match to d4i0za_
    complexed with 1m7, ni

Details for d4jpea1

PDB Entry: 4jpe (more details), 1.8 Å

PDB Description: Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors
PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d4jpea1:

Sequence; same for both SEQRES and ATOM records: (download)

>d4jpea1 b.50.1.2 (A:45-440) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d4jpea1:

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Timeline for d4jpea1:

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