SCOPe 2.08: Domain d4jpca1: 4jpc A:45-440

Lineage for d4jpca1 (4jpc A:45-440)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (329 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d4jpca1: 4jpc A:45-440 [223928]
   Other proteins in same PDB: d4jpca2
   automated match to d4i0za_
   complexed with 1m6, ni

Details for d4jpca1

PDB Entry: 4jpc, 1.8 Å

PDB Description: Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d4jpca1:

Sequence; same for both SEQRES and ATOM records:

>d4jpca1 b.50.1.2 (A:45-440) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
gsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrql
sstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwe
gilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmii
ggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrl
pkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsf
ritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfav
sachvhdefrtaavegpfvtldmedcgynipqtdes

Timeline for d4jpca1:

• d4jpca1 first appeared in SCOPe 2.03, called d4jpca_
  
• d4jpca1 appears in SCOPe 2.07