SCOPe 2.03: Domain d4jnka1: 4jnk A:1-159

Lineage for d4jnka1 (4jnk A:1-159)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.5: LDH N-terminal domain-like [51848] (9 proteins)

6. Protein Lactate dehydrogenase [51859] (17 species)

7. Species Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [63940] (3 PDB entries)

8. Domain d4jnka1: 4jnk A:1-159 [223911]
   Other proteins in same PDB: d4jnka2, d4jnkb2, d4jnkc2, d4jnkd2
   automated match to d1i10a1
   complexed with epe, lac, nai, so4, zhk

Details for d4jnka1

PDB Entry: 4jnk, 1.9 Å

PDB Description: Lactate Dehydrogenase A in complex with inhibitor compound 22

PDB Compounds: (A:) L-lactate dehydrogenase A chain

SCOPe Domain Sequences for d4jnka1:

Sequence, based on SEQRES records:

>d4jnka1 c.2.1.5 (A:1-159) Lactate dehydrogenase {Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]}
atlkdqliynllkeeqtpqnkitvvgvgavgmacaisilmkdladelalvdviedklkge
mmdlqhgslflrtpkivsgkdynvtansklviitagarqqegesrlnlvqrnvnifkfii
pnvvkyspnckllivsnpvdiltyvawkisgfpknrvig

Sequence, based on observed residues (ATOM records):

>d4jnka1 c.2.1.5 (A:1-159) Lactate dehydrogenase {Human (Homo sapiens), muscle isoform (M chain) [TaxId: 9606]}
atlkdqliynllkeeqtpqnkitvvgvgavgmacaisilmkdladelalvdviedklkge
mmdlqhgslflrtpkivsgkdynvtansklviitagarsrlnlvqrnvnifkfiipnvvk
yspnckllivsnpvdiltyvawkisgfpknrvig

Timeline for d4jnka1:

• d4jnka1 is new in SCOPe 2.03-stable
  
• d4jnka1 appears in SCOPe 2.04
  
• d4jnka1 appears in the current release, SCOPe 2.08