SCOPe 2.08: Domain d4jlgb2: 4jlg B:194-363

Lineage for d4jlgb2 (4jlg B:194-363)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.85: beta-clip [51268] (7 superfamilies)
   double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll

4. Superfamily b.85.7: SET domain [82199] (4 families)
   duplication: the core is composed of two structural repeats similar to (circularly permuted) repeats of AFPIII
   also contains a substrate-binding alpha+beta subdomain inserted in the core
   Pfam PF00856

5. Family b.85.7.1: Histone lysine methyltransferases [82200] (3 proteins)
   contains metal-binding preSET (Pfam PF05033) or AWS (Associated With SET, Pfam PF17907), and postSET domains

6. Protein Histone H3 K4-specific methyltransferase SET7/9 catalytic domain [82205] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [82206] (19 PDB entries)
   Uniprot Q8WTS6 52-336

8. Domain d4jlgb2: 4jlg B:194-363 [223886]
   Other proteins in same PDB: d4jlga1, d4jlgb1
   automated match to d3cbpa2
   complexed with 1l8, sam, unx

Details for d4jlgb2

PDB Entry: 4jlg, 1.9 Å

PDB Description: SETD7 in complex with inhibitor (R)-PFI-2 and S-adenosyl-methionine

PDB Compounds: (B:) Histone-lysine N-methyltransferase SETD7

SCOPe Domain Sequences for d4jlgb2:

Sequence; same for both SEQRES and ATOM records:

>d4jlgb2 b.85.7.1 (B:194-363) Histone H3 K4-specific methyltransferase SET7/9 catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
dkstsscistnallpdpyeservyvaeslissageglfskvavgpntvmsfyngvrithq
evdsrdwalngntlsldeetvidvpepynhvskycaslghkanhsftpnciydmfvhprf
gpikcirtlraveadeeltvaygydhsppgksgpeapewyqvelkafqat

Timeline for d4jlgb2:

• d4jlgb2 first appeared in SCOPe 2.03
  
• d4jlgb2 appears in SCOPe 2.07