Lineage for d4jlgb2 (4jlg B:194-363)

  1. Root: SCOPe 2.07
  2. 2352458Class b: All beta proteins [48724] (178 folds)
  3. 2427208Fold b.85: beta-clip [51268] (7 superfamilies)
    double-stranded ribbon sharply bent in two places; the ribbon ends form incomplete barrel; jelly-roll
  4. 2427940Superfamily b.85.7: SET domain [82199] (4 families) (S)
    duplication: the core is composed of two structural repeats similar to (circularly permuted) repeats of AFPIII
    also contains a substrate-binding alpha+beta subdomain inserted in the core
  5. 2427941Family b.85.7.1: Histone lysine methyltransferases [82200] (3 proteins)
    contains metal-binding preSET and postSET domains
  6. 2427947Protein Histone H3 K4-specific methyltransferase SET7/9 catalytic domain [82205] (1 species)
  7. 2427948Species Human (Homo sapiens) [TaxId:9606] [82206] (19 PDB entries)
    Uniprot Q8WTS6 52-336
  8. 2427962Domain d4jlgb2: 4jlg B:194-363 [223886]
    Other proteins in same PDB: d4jlga1, d4jlgb1
    automated match to d3cbpa2
    complexed with 1l8, sam, unx

Details for d4jlgb2

PDB Entry: 4jlg (more details), 1.9 Å

PDB Description: SETD7 in complex with inhibitor (R)-PFI-2 and S-adenosyl-methionine
PDB Compounds: (B:) Histone-lysine N-methyltransferase SETD7

SCOPe Domain Sequences for d4jlgb2:

Sequence; same for both SEQRES and ATOM records: (download)

>d4jlgb2 b.85.7.1 (B:194-363) Histone H3 K4-specific methyltransferase SET7/9 catalytic domain {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d4jlgb2:

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Timeline for d4jlgb2:

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