SCOPe 2.06: Domain d4hxsa1: 4hxs A:44-166

Lineage for d4hxsa1 (4hxs A:44-166)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.29: Bromodomain-like [47363] (15 superfamilies)
   4 helices; bundle; minor mirror variant of up-and-down topology

4. Superfamily a.29.2: Bromodomain [47370] (2 families)

5. Family a.29.2.0: automated matches [191428] (1 protein)
   not a true family

6. Protein automated matches [190615] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187641] (647 PDB entries)

8. Domain d4hxsa1: 4hxs A:44-166 [222782]
   Other proteins in same PDB: d4hxsa2
   automated match to d3uvya_
   complexed with 1a3

Details for d4hxsa1

PDB Entry: 4hxs, 1.43 Å

PDB Description: brd4 bromodomain 1 complex with n-[3-(2-oxo-2,3-dihydro-1,3-thiazol-4-yl)phenyl]-1-phenylmethanesulfonamide inhibitor

PDB Compounds: (A:) Bromodomain-containing protein 4

SCOPe Domain Sequences for d4hxsa1:

Sequence; same for both SEQRES and ATOM records:

>d4hxsa1 a.29.2.0 (A:44-166) automated matches {Human (Homo sapiens) [TaxId: 9606]}
nppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiikt
pmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkine
lpt

Timeline for d4hxsa1:

• d4hxsa1 first appeared in SCOPe 2.03, called d4hxsa_
  
• d4hxsa1 was called d4hxsa_ in SCOPe 2.05
  
• d4hxsa1 appears in SCOPe 2.07
  
• d4hxsa1 appears in the current release, SCOPe 2.08