SCOPe 2.03: Domain d4g2ya_: 4g2y A:

Lineage for d4g2ya_ (4g2y A:)

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein automated matches [190370] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187208] (22 PDB entries)

8. Domain d4g2ya_: 4g2y A: [221674]
   automated match to d3siea_
   complexed with mg, ni5, peg, zn

Details for d4g2ya_

PDB Entry: 4g2y, 2.4 Å

PDB Description: Crystal structure of PDE5A complexed with its inhibitor

PDB Compounds: (A:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d4g2ya_:

Sequence, based on SEQRES records:

>d4g2ya_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
meetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhe
vlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalsh
dldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttl
kiikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwp
iqqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealt
hvsedcfplldgcrknrqkwqalae

Sequence, based on observed residues (ATOM records):

>d4g2ya_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
meetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhe
vlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalsh
dldhrgvnnsplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlkiikqai
latdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriae
lvateffdknkipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalae

Timeline for d4g2ya_:

• d4g2ya_ is new in SCOPe 2.03-stable
  
• d4g2ya_ appears in SCOPe 2.04
  
• d4g2ya_ appears in the current release, SCOPe 2.08, called d4g2ya1