SCOP 1.69: Domain d1a22b2: 1a22 B:329-437

Lineage for d1a22b2 (1a22 B:329-437)

1. Root: SCOP 1.69

2. Class b: All beta proteins [48724] (144 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (23 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.2: Fibronectin type III [49265] (1 family)

5. Family b.1.2.1: Fibronectin type III [49266] (24 proteins)

6. Protein Growth hormone receptor [49280] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [49281] (6 PDB entries)
   tandem of fibronectin type III domains

8. Domain d1a22b2: 1a22 B:329-437 [22004]
   Other proteins in same PDB: d1a22a_

Details for d1a22b2

PDB Entry: 1a22, 2.6 Å

PDB Description: human growth hormone bound to single receptor

SCOP Domain Sequences for d1a22b2:

Sequence, based on SEQRES records:

>d1a22b2 b.1.2.1 (B:329-437) Growth hormone receptor {Human (Homo sapiens)}
vqpdppialnwtllnvsltgihadiqvrweaprnadiqkgwmvleyelqykevnetkwkm
mdpilttsvpvyslkvdkeyevrvrskqrnsgnygefsevlyvtlpqms

Sequence, based on observed residues (ATOM records):

>d1a22b2 b.1.2.1 (B:329-437) Growth hormone receptor {Human (Homo sapiens)}
vqpdppialnwtllngihadiqvrweaprnadiqkgwmvleyelqykevnetkwkmmdpi
lttsvpvyslkvdkeyevrvrskqrnsgnygefsevlyvtlpqms

Timeline for d1a22b2:

• d1a22b2 first appeared (with stable ids) in SCOP 1.55
  
• d1a22b2 appears in SCOP 1.67
  
• d1a22b2 appears in SCOP 1.71
  
• d1a22b2 appears in the current release, SCOPe 2.08