SCOPe 2.04: Domain d3v5qa_: 3v5q A:

Lineage for d3v5qa_ (3v5q A:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (19 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (476 PDB entries)

8. Domain d3v5qa_: 3v5q A: [217673]
   automated match to d3rhxa_
   complexed with 0f4, cl

Details for d3v5qa_

PDB Entry: 3v5q, 2.2 Å

PDB Description: discovery of a selective trk inhibitor with efficacy in rodent cancer tumor models

PDB Compounds: (A:) NT-3 growth factor receptor

SCOPe Domain Sequences for d3v5qa_:

Sequence, based on SEQRES records:

>d3v5qa_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gihvqhikrrdivlkrelgegafgkvflaecynlsptkdkmlvavkalkdptlaarkdfq
reaelltnlqhehivkfygvcgdgdplimvfeymkhgdlnkflrahgpdamilvdgqprq
akgelglsqmlhiasqiasgmvylasqhfvhrdlatrnclvganllvkigdfgmsrdvys
tdyyrvgghtmlpirwmppesimyrkfttesdvwsfgvilweiftygkqpwfqlsntevi
ecitqgrvlerprvcpkevydvmlgcwqrepqqrlnikeiykilhalgkatp

Sequence, based on observed residues (ATOM records):

>d3v5qa_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
gihvqhikrrdivlkrelkvflaecynlsptkdkmlvavkalptlaarkdfqreaelltn
lqhehivkfygvcgdgdplimvfeymkhgdlnkflrahgpelglsqmlhiasqiasgmvy
lasqhfvhrdlatrnclvganllvkigdfgmdvystdyyrtmlpirwmppesimyrkftt
esdvwsfgvilweiftygkqpwfqlsnteviecitqgrvlerprvcpkevydvmlgcwqr
epqqrlnikeiykilhalgkatp

Timeline for d3v5qa_:

• d3v5qa_ first appeared in SCOPe 2.03
  
• d3v5qa_ appears in SCOPe 2.05
  
• d3v5qa_ appears in the current release, SCOPe 2.08, called d3v5qa1