SCOPe 2.03: Domain d3tsea_: 3tse A:

Lineage for d3tsea_ (3tse A:)

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein automated matches [190370] (1 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187208] (22 PDB entries)

8. Domain d3tsea_: 3tse A: [217024]
   automated match to d3siea_
   complexed with 5eo, mg, zn

Details for d3tsea_

PDB Entry: 3tse, 2.14 Å

PDB Description: crystal structure of the pde5a1 catalytic domain in complex with novel inhibitors

PDB Compounds: (A:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d3tsea_:

Sequence, based on SEQRES records:

>d3tsea_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
meetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhe
vlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalsh
dldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttl
kiikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwp
iqqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealt
hvsedcfplldgcrknrqkwqalaeqq

Sequence, based on observed residues (ATOM records):

>d3tsea_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
meetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhe
vlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalsh
dldhrgvnnsyiqrsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailatd
lalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvat
effdqgknkipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalaeqq

Timeline for d3tsea_:

• d3tsea_ is new in SCOPe 2.03-stable
  
• d3tsea_ appears in SCOPe 2.04
  
• d3tsea_ last appears in SCOPe 2.05