PDB entry 3tse

View 3tse on RCSB PDB site
Description: Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
Class: hydrolase/hydrolase inhibitor
Keywords: PDE5A1, PDE5A inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2011-09-13, released 2012-09-19
Made obsolete by 4oex on 2015-04-01

The last revision prior to the SCOPe 2.03 freeze date was dated 2012-09-19, with a file datestamp of 2012-09-14.
Experiment type: XRAY
Resolution: 2.14 Å
R-factor: 0.192
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cGMP-specific 3',5'-cyclic phosphodiesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE5, PDE5A
    Database cross-references and differences (RAF-indexed):
    • Uniprot O76074 (21-346)
      • expression tag (20)
    Domains in SCOPe 2.03: d3tsea_
  • Heterogens: 5EO, MG, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3tseA (A:)
mgsshhhhhhssglvprgshmeetrelqslaaavvpsaqtlkitdfsfsdfelsdletal
ctirmftdlnlvqnfqmkhevlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagk
iqnkltdleilalliaalshdldhrgvnnsyiqrsehplaqlychsimehhhfdqclmil
nspgnqilsglsieeykttlkiikqailatdlalyikrrgeffelirknqfnledphqke
lflamlmtacdlsaitkpwpiqqriaelvateffdqgdrerkelnieptdlmnrekknki
psmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalaeqq

    Sequence, based on observed residues (ATOM records): (download) 
    >3tseA (A:)
meetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhe
vlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalsh
dldhrgvnnsyiqrsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailatd
lalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvat
effdqgknkipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalaeqq