SCOPe 2.03: Domain d3orxf_: 3orx F:

Lineage for d3orxf_ (3orx F:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (18 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (314 PDB entries)

8. Domain d3orxf_: 3orx F: [214509]
   automated match to d4eopc_
   complexed with 1f8, cl; mutant

Details for d3orxf_

PDB Entry: 3orx, 2.2 Å

PDB Description: PDK1 mutant bound to allosteric disulfide fragment inhibitor 1F8

PDB Compounds: (F:) 3-phosphoinositide-dependent protein kinase 1

SCOPe Domain Sequences for d3orxf_:

Sequence, based on SEQRES records:

>d3orxf_ d.144.1.0 (F:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdvm
srldhpffvklyfcfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsale
ylhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvspell
teksackssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlve
kllvldatkrlgceemegygplkahpffesvtwenlhqqtppklt

Sequence, based on observed residues (ATOM records):

>d3orxf_ d.144.1.0 (F:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
rkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdvm
srldhpffvklyfcfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsale
ylhgkgiihrdlkpenillnedmhiqitdfgtakvlsfvgtaqyvspellteksackssd
lwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekllvldatkr
lgceemegygplkahpffesvtwenlhqqtppklt

Timeline for d3orxf_:

• d3orxf_ is new in SCOPe 2.03-stable
  
• d3orxf_ appears in SCOPe 2.04
  
• d3orxf_ appears in the current release, SCOPe 2.08