SCOPe 2.08: Domain d3lxna_: 3lxn A:

Lineage for d3lxna_ (3lxn A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (37 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (1476 PDB entries)

8. Domain d3lxna_: 3lxn A: [213093]
   automated match to d3lpbb_
   complexed with mi1

Details for d3lxna_

PDB Entry: 3lxn, 2.5 Å

PDB Description: structural and thermodynamic characterization of the tyk2 and jak3 kinase domains in complex with cp-690550 and cmp-6

PDB Compounds: (A:) Non-receptor tyrosine-protein kinase TYK2

SCOPe Domain Sequences for d3lxna_:

Sequence, based on SEQRES records:

>d3lxna_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dptvfhkrylkkirdlgeghfgkvslycydptndgtgemvavkalkadagpqhrsgwkqe
idilrtlyhehiikykgccedagaaslqlvmeyvplgslrdylprhsiglaqlllfaqqi
cegmaylhaqhyihrdlaarnvlldndrlvkigdfglakavpegheyyrvredgdspvfw
yapeclkeykfyyasdvwsfgvtlyellthcdssqspptkfleligiaqgqmtvlrltel
lergerlprpdkcpaevyhlmkncweteasfrptfenlipilktvhekyqg

Sequence, based on observed residues (ATOM records):

>d3lxna_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dptvfhkrylkkirdlgeghfgkvslycydptndgtgemvavkalkadagpqhrsgwkqe
idilrtlyhehiikykgccedagaaslqlvmeyvplgslrdylprhsiglaqlllfaqqi
cegmaylhaqhyihrdlaarnvlldndrlvkigdfglakavpegheyyrvgdspvfwyap
eclkeykfyyasdvwsfgvtlyellthcdssqspptkfleligiaqgqmtvlrlteller
gerlprpdkcpaevyhlmkncweteasfrptfenlipilktvhekyqg

Timeline for d3lxna_:

• d3lxna_ first appeared in SCOPe 2.03
  
• d3lxna_ appears in SCOPe 2.07