PDB entry 3lxn

View 3lxn on RCSB PDB site
Description: Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6
Class: transferase
Keywords: TYK2, JAK3, inflammation, cancer, PAN Inhibitor, ATP-binding, Kinase, Nucleotide-binding, Phosphoprotein, SH2 domain, Transferase, Tyrosine-protein kinase
Deposited on 2010-02-25, released 2010-06-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2010-07-28, with a file datestamp of 2010-07-23.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.223
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Non-receptor tyrosine-protein kinase TYK2
    Species: Homo sapiens [TaxId:9606]
    Gene: TYK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29597 (23-End)
      • engineered (71)
      • engineered (104)
      • engineered (106-107)
      • engineered (277)
    Domains in SCOPe 2.08: d3lxna_
  • Heterogens: MI1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3lxnA (A:)
mahhhhhhhhhhgalevlfqgpgdptvfhkrylkkirdlgeghfgkvslycydptndgtg
emvavkalkadagpqhrsgwkqeidilrtlyhehiikykgccedagaaslqlvmeyvplg
slrdylprhsiglaqlllfaqqicegmaylhaqhyihrdlaarnvlldndrlvkigdfgl
akavpegheyyrvredgdspvfwyapeclkeykfyyasdvwsfgvtlyellthcdssqsp
ptkfleligiaqgqmtvlrltellergerlprpdkcpaevyhlmkncweteasfrptfen
lipilktvhekyqgqaps

    Sequence, based on observed residues (ATOM records): (download) 
    >3lxnA (A:)
dptvfhkrylkkirdlgeghfgkvslycydptndgtgemvavkalkadagpqhrsgwkqe
idilrtlyhehiikykgccedagaaslqlvmeyvplgslrdylprhsiglaqlllfaqqi
cegmaylhaqhyihrdlaarnvlldndrlvkigdfglakavpegheyyrvgdspvfwyap
eclkeykfyyasdvwsfgvtlyellthcdssqspptkfleligiaqgqmtvlrlteller
gerlprpdkcpaevyhlmkncweteasfrptfenlipilktvhekyqg