SCOPe 2.04: Domain d3fsua_: 3fsu A:

Lineage for d3fsua_ (3fsu A:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.23: FAD-linked oxidoreductase [51730] (2 families)
   distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation

5. Family c.1.23.1: Methylenetetrahydrofolate reductase [51731] (2 proteins)
   automatically mapped to Pfam PF02219

6. Protein automated matches [193645] (2 species)
   not a true protein

7. Species Escherichia coli K-12 [TaxId:83333] [225710] (2 PDB entries)

8. Domain d3fsua_: 3fsu A: [210090]
   automated match to d1b5tb_
   complexed with c2f, fad, mry, so4; mutant

Details for d3fsua_

PDB Entry: 3fsu, 1.7 Å

PDB Description: crystal structure of escherichia coli methylenetetrahydrofolate reductase double mutant phe223leuglu28gln complexed with methyltetrahydrofolate

PDB Compounds: (A:) 5,10-Methylenetetrahydrofolate reductase

SCOPe Domain Sequences for d3fsua_:

Sequence, based on SEQRES records:

>d3fsua_ c.1.23.1 (A:) automated matches {Escherichia coli K-12 [TaxId: 83333]}
ffhasqrdalnqslaevqgqinvsfqffpprtsemeqtlwnsidrlsslkpkfvsvtyga
nsgerdrthsiikgikdrtgleaaphltcidatpdelrtiardywnngirhivalrgdlp
pgsgkpemyasdlvtllkevadfdisvaaypevhpeaksaqadllnlkrkvdaganrait
qfffdvesylrfrdrcvsagidveiipgilpvsnfkqakkladmtnvripawmaqmfdgl
dddaetrklvganiamdmvkilsregvkdfhfytlnraemsyaichtlgvrp

Sequence, based on observed residues (ATOM records):

>d3fsua_ c.1.23.1 (A:) automated matches {Escherichia coli K-12 [TaxId: 83333]}
ffhasqrdalnqslaevqgqinvsfqffpprtsemeqtlwnsidrlsslkpkfvsvtyga
nsgerdrthsiikgikdrtgleaaphltcidatpdelrtiardywnngirhivalrgdle
myasdlvtllkevadfdisvaaypevhpeaksaqadllnlkrkvdaganraitqfffdve
sylrfrdrcvsagidveiipgilpvsnfkqakkladmtnvripawmaqmfdgldddaetr
klvganiamdmvkilsregvkdfhfytlnraemsyaichtlgvrp

Timeline for d3fsua_:

• d3fsua_ first appeared in SCOPe 2.03
  
• d3fsua_ appears in SCOPe 2.05
  
• d3fsua_ appears in the current release, SCOPe 2.08