SCOPe 2.07: Domain d3eqca_: 3eqc A:

Lineage for d3eqca_ (3eqc A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Dual specificity mitogen-activated protein kinase kinase 1, Mek1 [118137] (2 species)
   OPK group (?); MAPKK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [118138] (42 PDB entries)
   Uniprot Q02750 61-381

8. Domain d3eqca_: 3eqc A: [209608]
   automated match to d1s9ia_
   complexed with 3bm, ags, ca, mg, na

Details for d3eqca_

PDB Entry: 3eqc, 1.8 Å

PDB Description: x-ray structure of the human mitogen-activated protein kinase kinase 1 (mek1) in a ternary complex with compound 1, atp-gs and mg2p

PDB Compounds: (A:) Dual specificity mitogen-activated protein kinase kinase 1

SCOPe Domain Sequences for d3eqca_:

Sequence, based on SEQRES records:

>d3eqca_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
eleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarkl
ihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkka
gripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlids
mansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcq
vegdaaetpprprtpgrplnkfgmdsrppmaifelldyivnepppklpsgvfslefqdfv
nkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstigln

Sequence, based on observed residues (ATOM records):

>d3eqca_ d.144.1.7 (A:) Dual specificity mitogen-activated protein kinase kinase 1, Mek1 {Human (Homo sapiens) [TaxId: 9606]}
eleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarkl
ihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkka
gripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlids
mavgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmfgcpmai
felldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevd
fagwlcstigln

Timeline for d3eqca_:

• d3eqca_ first appeared in SCOPe 2.03
  
• d3eqca_ appears in SCOPe 2.06
  
• d3eqca_ appears in the current release, SCOPe 2.08