SCOPe 2.04: Domain d3enmc_: 3enm C:

Lineage for d3enmc_ (3enm C:)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (19 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (476 PDB entries)

8. Domain d3enmc_: 3enm C: [209563]
   automated match to d3mbla_
   complexed with edo, gol, so4

Details for d3enmc_

PDB Entry: 3enm, 2.35 Å

PDB Description: the structure of the map2k mek6 reveals an autoinhibitory dimer

PDB Compounds: (C:) Dual specificity mitogen-activated protein kinase kinase 6

SCOPe Domain Sequences for d3enmc_:

Sequence, based on SEQRES records:

>d3enmc_ d.144.1.0 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vkaddlepimelgrgaygvvekmrhvpsgqimavkriratvnsqeqkrllmdldismrtv
dcpftvtfygalfregdvwicmelmdtsldkfykqvidkgqtipedilgkiavsivkale
hlhsklsvihrdvkpsnvlinalgqvkmcdfgisgylvddvakdidagckpymaperinp
elnqkgysvksdiwslgitmielailrfpydswgtpfqqlkqvveepspqlpadkfsaef
vdftsqclkknskerptypelmqhpfftlheskgtdvasfvklila

Sequence, based on observed residues (ATOM records):

>d3enmc_ d.144.1.0 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vkaddlepimelgrgaygvvekmrhvpsgqimavkriratvnsqeqkrllmdldismrtv
dcpftvtfygalfregdvwicmelmdtsldkfykqvidkgqtipedilgkiavsivkale
hlhsklsvihrdvkpsnvlinalgqvkmcdfgisgylvddvkpymaperinpelnqsvks
diwslgitmielailrfpydswgtpfqqlkqvveepspqlpadkfsaefvdftsqclkkn
skerptypelmqhpfftlheskgtdvasfvklila

Timeline for d3enmc_:

• d3enmc_ first appeared in SCOPe 2.03
  
• d3enmc_ appears in SCOPe 2.05
  
• d3enmc_ appears in the current release, SCOPe 2.08, called d3enmc1