SCOPe 2.03: Domain d2rgpa_: 2rgp A:

Lineage for d2rgpa_ (2rgp A:)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (38 PDB entries)
   Uniprot P00533 702-1018

8. Domain d2rgpa_: 2rgp A: [206100]
   automated match to d3gt8b_
   complexed with hyz, po4

Details for d2rgpa_

PDB Entry: 2rgp, 2 Å

PDB Description: structure of egfr in complex with hydrazone, a potent dual inhibitor

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d2rgpa_:

Sequence, based on SEQRES records:

>d2rgpa_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
allrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankeild
eayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqi
akgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpikwm
alesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppicti
dvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyral
mdeedmddvvdadey

Sequence, based on observed residues (ATOM records):

>d2rgpa_ d.144.1.7 (A:) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
allrilketefkkikvlgsgafgtvykglwipvkipvaikelrkankeildeayvmasvd
nphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyllnwcvqiakgmnyled
rrlvhrdlaarnvlvktpqhvkitdfglakllgaeekvpikwmalesilhriythqsdvw
sygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcwmidadsr
pkfreliiefskmardpqrylviqgdermnfyralmdvvdadey

Timeline for d2rgpa_:

• d2rgpa_ is new in SCOPe 2.03-stable
  
• d2rgpa_ appears in SCOPe 2.04
  
• d2rgpa_ appears in the current release, SCOPe 2.08