SCOPe 2.06: Domain d2a4za4: 2a4z A:726-1087

Lineage for d2a4za4 (2a4z A:726-1087)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (1 protein)

6. Protein Phoshoinositide 3-kinase (PI3K), catalytic domain [56172] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56174] (65 PDB entries)

8. Domain d2a4za4: 2a4z A:726-1087 [203393]
   Other proteins in same PDB: d2a4za1, d2a4za2, d2a4za3
   automated match to d1e8ya4
   complexed with bym

Details for d2a4za4

PDB Entry: 2a4z, 2.9 Å

PDB Description: crystal structure of human pi3kgamma complexed with as604850

PDB Compounds: (A:) Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform

SCOPe Domain Sequences for d2a4za4:

Sequence, based on SEQRES records:

>d2a4za4 d.144.1.4 (A:726-1087) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrv
pydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlil
qilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkde
vlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidf
ghilgnyksflginkervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtn
lliilfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfn
wf

Sequence, based on observed residues (ATOM records):

>d2a4za4 d.144.1.4 (A:726-1087) Phoshoinositide 3-kinase (PI3K), catalytic domain {Human (Homo sapiens) [TaxId: 9606]}
tamlhdftqqvqviemlqkvtldikslvisqlkqklenlqnsqlpesfrvpydpglkaga
laiekckvmaskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiw
etesldlcllpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkeks
pteekfqaaverfvyscagycvatfvlgigdrhndnimitetgnlfhidfervpfvltpd
flfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpqltskediey
irdaltvgkneedakkyfldqievcrdkgwtvqfnwf

Timeline for d2a4za4:

• d2a4za4 first appeared in SCOPe 2.03
  
• d2a4za4 appears in SCOPe 2.05
  
• d2a4za4 appears in SCOPe 2.07
  
• d2a4za4 appears in the current release, SCOPe 2.08