SCOPe 2.08: Domain d3t3cb_: 3t3c B:

Lineage for d3t3cb_ (3t3c B:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (9 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (590 PDB entries)
   Uniprot P35963 57-155 ! Uniprot P04587 69-167 ! Uniprot P03366 69-167 ! Uniprot P03367 69-167 ! Uniprot P03368 69-167

8. Domain d3t3cb_: 3t3c B: [200745]
   automated match to d3t3ca_
   complexed with 017, bme, so4; mutant

Details for d3t3cb_

PDB Entry: 3t3c, 2.1 Å

PDB Description: Structure of HIV PR resistant patient derived mutant (comprising 22 mutations) in complex with DRV

PDB Compounds: (B:) hiv-1 protease

SCOPe Domain Sequences for d3t3cb_:

Sequence; same for both SEQRES and ATOM records:

>d3t3cb_ b.50.1.1 (B:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 [TaxId: 11676]}
pqislwqrpvvtariggqlievlldtgaddtviedidlpgkwspkmiagiggfvkvrqyd
qiliefcgkkaigsvlvgptpanvigrnimsqigctlnf

Timeline for d3t3cb_:

• d3t3cb_ first appeared in SCOPe 2.03
  
• d3t3cb_ appears in SCOPe 2.07