Lineage for Family b.50.1.1: Retroviral protease (retropepsin)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2058814Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 2058815Superfamily b.50.1: Acid proteases [50630] (4 families) (S)
  5. 2058816Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 protein domains)
    dimer of identical mono-domain chains, each containing (6,10) barrel

Protein Domains:

  1. 2058817EIAV protease [50644] (1 species)
  2. 2058821Feline immunodeficiency virus (FIV) protease [50638] (1 species)
  3. 2058832Human immunodeficiency virus type 1 protease [50632] (9 species)
    1. 2058833Species Hiv-1 m:b_arv2/sf2 [TaxId:11685] [187932] (17 PDB entries)
    2. 2058878Species Human immunodeficiency virus 1 [TaxId:11676] [224867] (50 PDB entries)
    3. 2058989Species Human immunodeficiency virus 2 [TaxId:11709] [195770] (1 PDB entry)
    4. 2058992Species Human immunodeficiency virus type 1 (arv2/sf2 isolate) [311116] (2 PDB entries)
    5. 2058996Species Human immunodeficiency virus type 1 (bh5 isolate) [TaxId:11682] [186950] (7 PDB entries)
    6. 2059011Species Human immunodeficiency virus type 1 (bru isolate) [TaxId:11686] [194276] (21 PDB entries)
    7. 2059056Species Human immunodeficiency virus type 1 (isolate z2/cdc-z34 group m subtype d) [TaxId:11683] [189173] (1 PDB entry)
    8. 2059059Species Human immunodeficiency virus type 1 lw12.3 isolate [TaxId:82834] [189723] (3 PDB entries)
    9. 2059066Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (476 PDB entries)
      Uniprot P35963 57-155 ! Uniprot P04587 69-167 ! Uniprot P03366 69-167 ! Uniprot P03367 69-167 ! Uniprot P03368 69-167
  4. 2059984Human immunodeficiency virus type 2 (HIV-2) protease [50634] (2 species)
    1. 2059985Species Human immunodeficiency virus type 2 (isolate rod) [TaxId:11720] [187235] (3 PDB entries)
    2. 2059992Species Human immunodeficiency virus type 2 [TaxId:11709] [50635] (15 PDB entries)
  5. 2060025Mason-Pfizer monkey virus protease [82131] (1 species)
  6. 2060028Myeloblastosis-associated viral protease [50642] (1 species)
  7. 2060032Rous sarcoma virus protease [50640] (1 species)
  8. 2060038Simian immunodeficiency virus (SIV) protease [50636] (1 species)
  9. 2060049automated matches [190433] (11 species)
    not a true protein
    1. 2060050Species Feline immunodeficiency virus (isolate petaluma) [TaxId:11674] [187795] (1 PDB entry)
    2. 2060052Species Feline immunodeficiency virus [TaxId:11673] [189983] (2 PDB entries)
    3. 2060057Species Hiv-1 m:b_arv2/sf2 [TaxId:11685] [188968] (6 PDB entries)
    4. 2060072Species Human immunodeficiency virus 1 (z2/cdc-z34 isolate) [TaxId:11683] [189840] (10 PDB entries)
    5. 2060093Species Human immunodeficiency virus 1 [TaxId:11676] [187327] (25 PDB entries)
    6. 2060132Species Human immunodeficiency virus type 1 (bru isolate) [TaxId:11686] [188980] (3 PDB entries)
    7. 2060139Species Human immunodeficiency virus type 1 (z2/cdc-z34 isolate) [TaxId:11683] [189175] (1 PDB entry)
    8. 2060142Species Human immunodeficiency virus type 1 [TaxId:11686] [193487] (1 PDB entry)
    9. 2060145Species Human immunodeficiency virus [TaxId:11686] [311331] (1 PDB entry)
    10. 2060148Species Human immunodeficiency virus [TaxId:12721] [188065] (13 PDB entries)
    11. 2060174Species Mason-pfizer monkey virus [TaxId:11855] [189736] (1 PDB entry)

More info for Family b.50.1.1: Retroviral protease (retropepsin)

Timeline for Family b.50.1.1: Retroviral protease (retropepsin):