Lineage for d2iffh1 (2iff H:2-116)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2017115Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2017116Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2017117Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 protein domains)
  6. 2017323Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
    VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
  7. 2017824Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (181 PDB entries)
    Uniprot P01756 1-117 # 78% sequense identity; HV12_MOUSE Ig heavy chain V region MOPC 104E ! SQ NA # humanized antibody ! Uniprot P01750 # HV06_MOUSE Ig heavy chain V region 102 precursor ! Uniprot P01750 20-116 # ! HV06_MOUSE Ig heavy chain V region 102 precursor
  8. 2017990Domain d2iffh1: 2iff H:2-116 [19973]
    Other proteins in same PDB: d2iffh2, d2iffl1, d2iffl2, d2iffy_
    part of Fab HyHEL-5

Details for d2iffh1

PDB Entry: 2iff (more details), 2.65 Å

PDB Description: structure of an antibody-lysozyme complex: effect of a conservative mutation
PDB Compounds: (H:) igg1 hyhel-5 fab (heavy chain)

SCOPe Domain Sequences for d2iffh1:

Sequence; same for both SEQRES and ATOM records: (download)

>d2iffh1 b.1.1.1 (H:2-116) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 3.2 [TaxId: 10090]}

SCOPe Domain Coordinates for d2iffh1:

Click to download the PDB-style file with coordinates for d2iffh1.
(The format of our PDB-style files is described here.)

Timeline for d2iffh1: