SCOPe 2.07: Domain d4gcja1: 4gcj A:1-298

Lineage for d4gcja1 (4gcj A:1-298)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (413 PDB entries)
   Uniprot P24941

8. Domain d4gcja1: 4gcj A:1-298 [197092]
   Other proteins in same PDB: d4gcja2
   automated match to d3pxza_
   complexed with edo, x64

Details for d4gcja1

PDB Entry: 4gcj, 1.42 Å

PDB Description: CDK2 in complex with inhibitor RC-3-89

PDB Compounds: (A:) cyclin-dependent kinase 2

SCOPe Domain Sequences for d4gcja1:

Sequence; same for both SEQRES and ATOM records:

>d4gcja1 d.144.1.7 (A:1-298) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Timeline for d4gcja1:

• d4gcja1 first appeared in SCOPe 2.02, called d4gcja_
  
• d4gcja1 appears in SCOPe 2.06
  
• d4gcja1 appears in the current release, SCOPe 2.08