SCOPe 2.04: Domain d4fqfd_: 4fqf D:

Lineage for d4fqfd_ (4fqf D:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.82: ALDH-like [53719] (1 superfamily)
   consists of two similar domains with 3 layers (a/b/a) each; duplication
   core: parallel beta-sheet of 5 strands, order 32145

4. Superfamily c.82.1: ALDH-like [53720] (3 families)
   binds NAD differently from other NAD(P)-dependent oxidoreductases

5. Family c.82.1.1: ALDH-like [53721] (6 proteins)

6. Protein Aldehyde reductase (dehydrogenase), ALDH [53722] (9 species)

7. Species Human (Homo sapiens), mitochondrial [TaxId:9606] [53726] (25 PDB entries)
   Uniprot P05091

8. Domain d4fqfd_: 4fqf D: [194634]
   automated match to d1bi9a_
   complexed with 2no, mg, na, nad, ure

Details for d4fqfd_

PDB Entry: 4fqf, 2.28 Å

PDB Description: Crystal structure of a thionitrate intermediate of human aldehyde dehydrogenase-2

PDB Compounds: (D:) aldehyde dehydrogenase, mitochondrial

SCOPe Domain Sequences for d4fqfd_:

Sequence; same for both SEQRES and ATOM records:

>d4fqfd_ c.82.1.1 (D:) Aldehyde reductase (dehydrogenase), ALDH {Human (Homo sapiens), mitochondrial [TaxId: 9606]}
vpapnqqpevfcnqifinnewhdavsrktfptvnpstgevicqvaegdkedvdkavkaar
aafqlgspwrrmdashrgrllnrladlierdrtylaaletldngkpyvisylvdldmvlk
clryyagwadkyhgktipidgdffsytrhepvgvcgqiipwnfpllmqawklgpalatgn
vvvmkvaeqtpltalyvanlikeagfppgvvnivpgfgptagaaiashedvdkvaftgst
eigrviqvaagssnlkrvtlelggkspniimsdadmdwaveqahfalffnqgqcccagsr
tfvqediydefversvaraksrvvgnpfdskteqgpqvdetqfkkilgyintgkqegakl
lcgggiaadrgyfiqptvfgdvqdgmtiakeeifgpvmqilkfktieevvgrannstygl
aaavftkdldkanylsqalqagtvwvncydvfgaqspfggykmsgsgrelgeyglqayte
vktvtvkvpqkns

Timeline for d4fqfd_:

• d4fqfd_ first appeared in SCOPe 2.02
  
• d4fqfd_ appears in SCOPe 2.03
  
• d4fqfd_ appears in SCOPe 2.05
  
• d4fqfd_ appears in the current release, SCOPe 2.08